Sam Case claimed the west end of the bay front and named it Newport. Case and his friend Dr. J.R. Bayley built the Ocean House, probably the first resort hotel on Oregon's coast, on the site of the current Coast Guard station.

John Nye followed a creek flowing to the ocean and laid claim to land there, but the beachfront didn't develop until the late 1800s.

John and Joseph Graham, William Mackey, Royal Bensell, and others claimed land near what is now Toledo. Toledo's logging industry got a boost in 1917 when the Army built the infrastructure for a milling operation to produce lightweight wood for airplane construction during WWI.

The southern and northern areas of the Reservation were opened to settlement later. Waldport was founded and named by David Ruble in the fall of 1879. That same year Louis Southworth, a freed black slave, and James Doty homesteaded on the Alsea River.

The Ludemanns and Bobells, who had emigrated from Germany to Minnesota, moved on to Oregon and homesteaded on farms on the upper Yachats River. In 1887 the first post office in Ocean View (Yachats) was established about a mile north of the Yachats River.

The area now known as Depoe Bay is built on land allotted to Charley Depot and his family in 1894. Depot's name was given to him when he worked odd jobs at Depot Slough because his native name was difficult to pronounce. Some of Charley's descendents adopted the spelling D-e-P-o-e. In June 1927 the Sunset Investment Co. of Portland platted the town of DePoe Bay. In 1928, when a post office was approved, the spelling was simplified to Depoe Bay by the government.